Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a new technique to deliver intraperitoneal chemotherapy. During a standard laparoscopy, antitumor drugs are injected via a nebulizer (Capnomed) into the abdominal cavity where a therapeutic aerosol is formed. Data from ex-vivo studies, animal experiments, and human studies demonstrated a higher local drug bioavailability and a better therapeutic index after PIPAC compared to liquid IPC

 Clinical safety, feasibility, and anti-tumor efficacy of PIPAC have been reported in ovarian and gastrointestinal cancer patients with peritoneal carcinomatosis The feasibility of Pressurized IntraThoracal Aerosol Chemotherapy (PITAC) to palliate malignant pleural effusion has been reported previously